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Uganda
 
Sequence conservation and antibody cross-recognition of clade B human immunodeficiency virus (HIV) type 1 Tat protein in HIV-1-infected Italians, Ugandans, and South Africans
 
 
Journal of Infectious Diseases
Published:  October  15 2003
Posted:  April  20 2006
 
By  Butto S, et al
 
Abstract:

We determined immune cross-recognition and the degree of Tat conservation in patients infected by local human immunodeficiency virus (HIV) type 1 strains. The data indicated a similar prevalence of total and epitope-specific anti-Tat IgG in 578 serum samples from HIV-infected Italian (n=302), Ugandan (n=139), and South African (n=137) subjects, using the same B clade Tat protein that is being used in vaccine trials. In particular, anti-Tat antibodies were detected in 13.2%, 10.8%, and 13.9% of HIV-1-infected individuals from Italy, Uganda, and South Africa, respectively. Sequence analysis results indicated a high similarity of Tat from the different circulating viruses with BH-10 Tat, particularly in the 1-58 amino acid region, which contains most of the immunogenic epitopes. These data indicate an effective cross-recognition of a B-clade laboratory strain-derived Tat protein vaccine by individuals infected with different local viruses, owing to the high similarity of Tat epitopes.

PMID: 14551888

Author contact
Butto
Laboratory of Virology
Istituto Superiore di Sanita
University of Rome "La Sapienza,"
Rome, Italy

Offline source: J Infect Dis. 2003 Oct 15;188(8):1171-80. Epub 2003 Sep 30

Online source: Abstract

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Keywords: Uganda, Italy, South Africa, HIV, Antibody Cross-recognition, Sequence Conservation
 
 
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