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Cameroon
 
Cross-clade reactivity of HIV-1 specific T-cell responses in HIV-1 infected individuals from Botswana and Cameroon
 
 
Journal of Acquired Immune Deficiency Syndromes
Published:  June  1 2006
Posted:  June  11 2006
 
By  Gupta SB, et al
 
SUMMARY:

An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.

PMID: 16760794

Author contact
Gupta SB,
Merck and Co.,Inc.
Whitehouse Station
NJ, USA

Offline source: J Acquir Immune Defic Syndr. 2006 Jun;42(2):135-139.

Online source: Abstract
 
 
Keywords: Cameroon, HIV-1, T-cells.
 
 
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